Equipped for Tomorrow
Crop Protection Research - Safeners: a protective shield for crops
 

For farmers, wheat and wild oats are natural opposites. One is the most important cereal crop on our planet and serves as the raw material for many foods, while the other is a weed that mainly infests wheat fields and competes with the cereal for room to grow.

Modern crop protection provides farmers with the logical solution in the form of herbicides that only affect the weed, allowing the wheat to grow and flourish without impediment.

At first this solution appears straightforward, yet deeper consideration reveals a puzzle. Why should a product only attack the weed and not the crop? This apparent paradox is the result of extensive scientific research. For more than 30 years, biochemists have been investigating the physiology of plants and searching their enzymatic systems for characteristics that differentiate crops such as wheat, rice, corn or barley from their weed competitors.

High-throughput screening Using high-throughput screening, hundreds of thousands of substances can be tested each year for their potential as safeners in various herbicides for key crops.
 
Optimizing herbicides
The results of this work led to the development of additives for herbicides that are rapidly taken up by a crop's metabolic system, strengthening its natural defensive mechanisms against foreign substances and causing the herbicide to metabolize more quickly. These additives are called safeners, a name that clearly reflects their protective function - albeit one from which weeds do not benefit.

In recent years, major advances have been made in safener technology. For example, two substances researched in Frankfurt, Germany are combined with herbicides that can be used for a large number of different crops. Without safener technology, many of the most successful weed control agents would have had no chance in the market.

Molecular-biology-based diagnosis  Corinna van Almsick uses molecular-biology-based diagnosis to discover new safeners .

Multitalented additives
The acquisition of Aventis CropScience has taken Bayer to a position of global leadership in this field. Combining Bayer's new, promising herbicidal active ingredients with safener substances from Aventis' research opens up new perspectives for Bayer CropScience.

A whole series of substances that are believed to have safener properties is scheduled for further testing, promising new advances in crop protection. Scientists are working on safeners that should improve on what has so far been one of the main shortcomings of these substances: their limited spectrum of use. In the past, safeners have always been highly specialized substances with very limited applications, each one usually being suitable for only one crop and one herbicide.

This is about to change. Tomorrow's safeners will be suitable for both seed treatment and application to soil and plant leaves, as well as supporting various herbicides and exhibiting efficacy in several crops. One such multitalented substance recently developed by Bayer researchers is isoxadifen-diethyl. It protects rice, corn, sugar cane and wheat against various herbicides.

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  Bayer CropScience